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MOTS-c

10mg lyophilised · research peptide
$70 USD / vial In stock, ships Mon to Fri
MOTS-c research vial, Ai-Peptides
Made in the USASynthesised domestically
Tracked shippingShips Mon to Fri

MOTS-c

10mg lyophilised · research peptide
$70 USD / vial In stock, ships Mon to Fri
this batch, tested by an independent lab
Buy more, pay less volume price applies in cart
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Certificate of Analysis and Safety Data Sheet available for every batch.
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Product details

MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame within the mitochondrial 12S ribosomal RNA gene. It belongs to the mitochondrial-derived peptide class, a small group of signalling peptides read from the mitochondrial genome rather than the nuclear genome.

In the published preclinical literature, MOTS-c has been characterised at the molecular and cellular level for its association with the AMP-activated protein kinase (AMPK) pathway and for its translocation between cellular compartments under metabolic stress, where it has been studied as a signal in mitochondrial-to-nuclear gene-expression chemistry. It is supplied as a research compound and is not intended for human or veterinary use.

Form
Supplied as a lyophilised powder, 10mg per vial.
Vial size
10mg per vial.
CAS
1627580-64-6
Storage
Store the sealed lyophilised vial at -20°C, away from direct sunlight and protected from light.
Full specifications
Shelf life
The lyophilised form has a shelf life of up to 24 months when stored as directed.
Handling
Handle in accordance with standard laboratory safety practice. A Certificate of Analysis and a Safety Data Sheet are available on request.
Intended use
For research use only. Not for human or veterinary use. Not for use in diagnostic or therapeutic procedures.

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Research

MOTS-c has been characterised in preclinical laboratory models. The primary studies below, in cultured cell models, assayed molecular and pathway endpoints, with the work centred on AMP-activated protein kinase (AMPK) pathway markers and the peptide’s movement between cellular compartments under metabolic stress. The literature is preclinical; it describes the compound, not any outcome in humans.

2 preclinical studies indexed · mitochondrial-to-nuclear stress signalling and cellular energy-pathway signalling · links open on PubMed

Mitochondrial-to-nuclear stress signalling 1 study


In vitro
The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress
Kim et al. · 2018 · Cell Metabolism
In cultured cell lines (HEK293, HepG2, C2C12), the study assayed the peptide’s translocation to the nucleus and its AMPK-dependent association with nuclear gene-expression markers under glucose-restriction metabolic stress as a set of molecular endpoints.
Read the study ↗

Cellular energy-pathway signalling 1 study


In vitro
Mitofusion is required for MOTS-c induced GLUT4 translocation
Bhullar et al. · 2021 · Scientific Reports
In cultured mammalian cell lines, the study measured GLUT4 translocation, cellular glucose uptake, and the mitofusin GTPases OPA1 and MFN2, alongside mitochondrial-biogenesis markers (TFAM, NRF1, COX4), as molecular endpoints of the peptide’s cellular energy-pathway signalling.
Read the study ↗

Links open the original study on PubMed. For research and educational purposes, descriptive of the published preclinical literature, not therapeutic claims about any ai-peptides product. A Certificate of Analysis and a Safety Data Sheet are available on request for every batch.

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